The best private pathologist in Miami, Dr. Beaumont Rosewood, Jr., whose rare heart condition that could kill him at any moment fuels his lust for life, gives a second opinion when friends or family of the deceased are not satisfied with official police findings. His state-of-the-art laboratory equipment, Sherlock Holmes-like powers of deduction and quick wit are his main tools. He also relies and depends on his trusty assistants and cute couple, Pippy and TMI, and works with no-nonsense detective Annalise Villa, who doesn't always go strictly by the book, to see the case to its conclusion.

A group of heroic firefighters at Seattle Fire Station 19—from captain to newest recruit—risk their lives and hearts both in the line of duty and off the clock. These brave men and women are like family, literally and figuratively, and together they put their own lives in jeopardy as first responders to save the lives of others.